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The components of Fioricet work synergistically to address different aspects of headache pathology. Acetaminophen acts as a pain reliever and fever reducer, aiding in discomfort relief. Butalbital, a barbiturate, acts as a muscle relaxant and reduces tension and anxiety often associated with headaches. Caffeine serves as a central nervous system stimulant, augmenting the effects of acetaminophen and butalbital, thus enhancing overall pain relief.